A study presented at the 11th Annual AACR International Conference on Frontiers in Cancer Prevention Research shows that a high total intake of flavonoids may help lower the risk of highly aggressive prostate cancer.
Prior preclinical studies have shown that flavonoids have beneficial effects against prostate cancer, but few studies have examined the effect of flavonoids on prostate cancer in humans.
The researchers used data from 920 African-American men and 977 European-American men in the North Carolina–Louisiana Prostate Cancer Project who were newly diagnosed with prostate cancer. Participants completed a self-reported dietary history questionnaire to assess flavonoid intake, which was measured using the U.S. Dept. of Agriculture’s (USDA) 2011 Database for the Flavonoid Content of Selected Foods.
The researchers found that men with the highest total intake of flavonoids had a 25% lower risk for aggressive prostate cancer compared with those men with the lowest flavonoid intake.
“We found that higher total flavonoid intake was associated with reduced odds for aggressive prostate cancer in both African-American and European-American men, but no individual subclass of flavonoids appeared to be protective independently, suggesting that it is important to consume a variety of plant-based foods in the diet, rather than to focus on one specific type of flavonoid or flavonoid-rich food,” said Susan E. Steck, Associate Professor at the Arnold School of Public Health at the University of South Carolina.
In addition, the risk for aggressive prostate cancer was even lower in those men younger than 65 and in current smokers with the highest levels of flavonoid intake. Dietary questionnaire results revealed that citrus fruits and juices, such as oranges and grapefruits, tea, grapes, strawberries, onions, and cooked greens were the top contributors to total flavonoid intake among the participants.
“The results support public health recommendations and guidelines from organizations such as the American Institute for Cancer Research to consume a more plant-based diet,” said Steck. “In particular, consuming more flavonoid-rich foods may be beneficial for those people who are at increased risk for cancer, such as smokers.”