Researchers advance mapping of barley genome

A study published in the journal Nature shows that researchers have succeeded in mapping the most advanced sequencing of the barley genome—one of the world’s most important cereal crops—to date.

October 18, 2012

A study published in the journal Nature shows that researchers have succeeded in mapping the most advanced sequencing of the barley genome—one of the world’s most important cereal crops—to date. The advance will give researchers the tools to produce higher yields, improve pest and disease resistance, and enhance nutritional value of barley

“This important step toward full barley genome sequencing offers enormous potential for global food security. Using the tools of genetics and genomics, we are keeping farmers profitable and our food supply safe and abundant,” said Catherine Woteki, U.S. Dept. of Agriculture’s (USDA) Chief Scientist and Under Secretary for Research, Education, and Economics.

Along with project investigators Timothy Close and Stefano Lonardi at the University of California, Riverside (UCR) and Gary Muehlbauer at the University of Minnesota, supported by grants from USDA’s National Institute of Food and Agriculture (NIFA), USDA’s Agricultural Research Service (ARS) scientists Roger Wise and Jesse Poland, together with scientists from 19 other organizations around the world, make up the International Barley Sequencing Consortium (IBSC).

Nearly twice as large as the human or maize genomes, the barley genome was a challenge to sequence, due to its complexity and its large proportion of repetitive regions, which are difficult to piece together into a true linear order. By developing and applying a series of innovative strategies that allowed them to circumvent these difficulties, the IBSC created a high-resolution assembly that places the majority of barley genes in order. This new resource provides the sequences of nearly all genes and associated regulatory regions, which will offer new direction to researchers seeking to improve barley yield and quality through functional genomics (determining the functions of important barley genes) and genomics-assisted breeding.

The work of IBSC highlighted in Nature provides a detailed overview of the functional portions of the barley genome, revealing the order and structure of most of its 32,000 genes and a detailed analysis of where and when genes are switched on in different tissues and at different stages of development. The researchers describe the location of dynamic regions of the genome that carry genes conferring resistance to devastating diseases, such as powdery mildew, Fusarium head blight, and rusts. This will provide a far better understanding of the crop’s immune system. The achievement will also highlight the genetic differences among barley cultivars.

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