Researchers at Western University have identified a molecule found in oranges and tangerines that could hold the key to reversing obesity and regressing plaque build-up in arteries.
The molecule, called nobiletin, was given to mice that were fed a high-fat, high-cholesterol diet. The result was increased leanness and reduced levels of insulin resistance in the nobiletin-treated mice as compared with those that did not receive nobiletin.
Despite the impressive study results, researchers are stumped as to why the nobiletin works. One hypothesis is that the molecule acts on the pathway regulating how the body handles fat. The regulator, called AMP Kinase, prompts the body to burn fats to produce energy and blocks the manufacture of fats. However, the effects of nobiletin were evident even in mice that had been genetically modified to remove AMP Kinase.
Although the mechanism behind nobiletin remains a mystery, the fact that the molecule does not interfere with drugs that affect AMP Kinase is important because medications to treat diabetes, such as metformin, work through the pathway.
Studies in humans will help determine if the effects demonstrated in mice can be translated to human subjects. If so, the discovery could open the door to the development of new therapeutics to reduce obesity and its burden on the health-care system.
The dangers of a high-sodium diet have been well documented, but a new technology devised by scientists from Washington State University could help reduce sodium in processed foods while retaining taste and texture.
A study found that people who drank beverages that contained the low-calorie sweetener sucralose did experience metabolic problems and issues with neural responses but only when the beverage was formulated with both sucralose and a tasteless sugar (maltodextrin).
How the nonprofit group Kesho Congo formulates ready-to-use supplementary food from leaf protein concentrate in the Democratic Republic of Congo.
An infographic highlighting facts and figures related to diet and mental health.
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The National Honey Board (NHB) is currently accepting pre-proposals for honey food-pairings to help Americans consume a Mediterranean diet pattern. Interested researchers need to submit a short pre-proposal by November 13, 2020.
According to Innova Market Insights’ COVID-19 Consumer Survey (conducted in March 2020), in China, India, and Indonesia, personal concerns center on health, personal income, and the availability of healthcare and products to buy.
Following a long-term diet that’s low in carbohydrates and high in fat and protein from vegetables may reduce the risk of the most common subtype of glaucoma, according to a study published in Eye-Nature.
The U.S. FDA has announced in a letter of enforcement discretion that it does not intend to object to the use of certain qualified health claims regarding consuming certain cranberry products and a reduced risk of recurrent urinary tract infection in healthy women.
The 2020 DGAC revisited the topic of added sugars and concluded that a more appropriate target to help mitigate cardiovascular disease and obesity is to lower the number to 6% of energy from added sugars for the 2020–2025 Dietary Guidelines for Americans.