The concept that “food is medicine” is common to many cultures. Minora Shirota, the founder of Yakult Honsha, in Japan, had a straightforward philosophy: “Prevent disease rather than treat disease; a healthy intestine leads to a long life; and deliver health benefits to as many people as possible at an affordable price” (Heasman and Mellentin, 2001). This philosophy, elaborated almost half a century ago, is becoming more valid now than ever before. At the present level of scientific knowledge, t…

Fig. 1—Key steps in the process of angiogenesis, the formation of new blood vessels from preexisting vascular ones. (A) Secretion of angiogenic stimulus, such as proteases, by the tumor and degradation of the basement membrane. (B) Sprouting, elongation, migration, and proliferation of endothelial cells. (C) Association of endothelial cells into new tubular channels. (D) Synthesis of a new basement membrane and vessel maturation. Adapted from Wernert et al. (1999).

Fig. 2—Consequences of pathological angiogenesis.

Table 2—Strategies for angiogenesis inhibition. From Folkman and Ingber (1992)

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