The controversy regarding high-fructose corn syrup (HFCS) and obesity has been fueled by an array of reports—from food consumption assessments; meta-analyses of ecological, epidemiological, and longitudinal studies; and animal models—that are inconsistent and confusing. The overall strength of the evidence from four ecological studies, six cross-sectional studies, and seven longitudinal studies indicates that the association between the consumption of HFCS and overweight or obesity is limited at…

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