Dean Duxbury

What is a hyphenated analytical technique? The answer, according to a chapter on “Hyphenated Techniques” in Analytical Chemistry (Wiley-VCH, 1998), is “the marriage … of two separate analytical techniques via appropriate interfaces, usually with the backup of a computer tying everything together.”

Lab technicians compare analysis of pesticide residues using Waters’ Acquity UPLC™-MS-MS and HPLC-MS-MS. The narrower peak widths obtained by UPLC resulted in a signifi cant increase in signal response over that achieved under HPLC conditions.

In general, the term hyphenated techniques ranges from the combination of spectroscopic techniques (e.g., mass spectrometry) with chromatographic techniques (e.g., liquid chromatography or gas chromatog…

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