Next-Generation Sequencing Methods Revolutionize Food Microbiology
Application of whole genome sequencing technologies to food safety and food microbiology will dramatically change how we detect, subtype, and characterize foodborne pathogens, spoilage organisms, and starter cultures.
The first organism to have its entire genome sequence published was the RNA bacteriophage MS2 (in 1976); the first genome sequence from a DNA bacteriophage (Φ174) was published in 1977. Later that year, Sanger and colleagues published an article detailing the chain-termination sequencing technique, often called the Sanger sequencing method. For more than 20 years, the Sanger sequencing method was the only sequencing method available. The first bacterial genome sequenced by this method, Haemophil…
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