The United States is currently facing a major obesity epidemic, with 64% of the population being either overweight or obese. The concern is not unique to the U.S. but is spreading to the rest of the world at an alarming rate. The rapid increase in overweight children and adolescents over the past five years has triggered alarms with physicians, educators, and, more recently, politicians.

There is an unfortunate reality that currently most weight-loss programs simply do not work. Most overweight a…

Table 1—Negative health outcomes associated with obesity.

Fig.1—Factors leading to chronic inflammation.

Fig. 3—Hyperglycemia-induced oxidative stress activates NF-kB and development of vascular complications.

Fig. 4—Increasing levels of weight gain results in more macrophage recruitment to the adipose tissue and more inflammatory cytokine production.

Fig. 5—Antioxidants decrease inflammatory responses.

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